Description

Testosterone Propionate Landerlan

100mg x 10ml

Mechanism of Action and Pharmacokinetics:

Testosterone is absorbed in the gastrointestinal tract, through the skin and oral mucosa. However, it undergoes extensive hepatic first-pass metabolism when administered orally and is therefore usually administered intramuscularly, subcutaneously, or transdermally. In addition, the basic molecule of testosterone has been modified to obtain orally active derivatives and prolong the duration of the effect. Alkylation of the 17a position produces derivatives that are metabolized more slowly in the liver and, for this reason, can be administered orally. Esterification of the 17-hydroxyl group increases lipid solubility and leads to slower systemic absorption if administered by intramuscular injection. The rate of absorption of esters is related to the size of the ester group. Testosterone esters are hydrolyzed to testosterone after absorption.

Testosterone is approximately 80% bound to sex hormone binding globulin. 19-nostestosterone derivatives and 17α-methylated derivatives are characterized by reduced binding to this globulin. The plasma elimination half-life of testosterone ranges from 10 to 100 min. It is metabolized primarily in the liver via oxidation at the 17-OH group with the formation of androstenedione, which is further metabolized to the weakly androgenic androstenolone and inactive etiocholanolone, which are excreted in the urine primarily as glucuronoconjugates and sulfates. Approximately 6% is excreted unchanged in the faeces after undergoing enterohepatic recirculation. Testosterone is converted to the more active derivative dihydrotestosterone in some target organs by the effect of 5a-reductase.The 19-nortestosterone derivatives are less sensitive to this enzyme. Small amounts of testosterone are aromatized in the body, leading to the formation of estrogen derivatives in the body. Derivatives with a saturated A-ring, such as mesterolone, aromatize less to estrogen.

Indications:

It is used in the treatment of male hypogonadism. It is usually used in combination with testosterone enanthate.
It is used in acute renal failure in the form of oily solutions for intramuscular route, Topical route is used
It is used as an adjuvant in postmenopausal breast carcinoma, some postmenopausal disorders, and delayed puberty in children.

More information here!